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Euphol Acetate

Names

[ CAS No. ]:
13879-04-4

[ Name ]:
Euphol Acetate

Biological Activity

[Description]:

Euphol acetate is a triterpene that can be isolated from Euphorbia broteri. Euphol acetate is an inhibitor of hepatic transport proteins organic anion-transporting polypeptide 1/3 (OATP1B1/3)[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[Target]

OATP1B1/3[2]


[In Vitro]

Euphol acetate (10μM) suppresses the uptake of the OATP1B substrate sodium fluorescein in OATP1B1 (29.2%)- or 1B3 (40.2%)-transfected CHO cells[2].

[References]

[1]. DePascual Teresa, et al. Triterpenes from Euphorbia broteri. Phytochemistry. 1987. 26(6): 1767-1776.

[2]. Tom De Bruyn, et al. Structure-based identification of OATP1B1/3 inhibitors. Mol Pharmacol. 2013 Jun;83(6):1257-67.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H52O2

[ Molecular Weight ]:
468.75

Related Compounds