Zinpentraxin alfa

Zinpentraxin alfa (PRM-151) is a recombinant human pentraxin-2, also known as serum amyloid hSAP, a highly conserved serum protein and soluble pattern recognition receptor (PRR) of the innate immune system that regulates monocyte activation and differentiation. Zinpentraxin alfa inhibits the differentiation of circulating monocytes into fibroblasts and pro-fibroblastic macrophages and suppresses myofibroblast production[1].

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

Zinpentraxin alfa（PRM-151）（20 mg/mL，局部 30 μL，每天6 次，连续 5 天或 200 μL 结膜下注射，每隔一天，直到第 8 天）通过局部治疗使家兔前角膜基质中出现大量的肌成纤维细胞标志物α平滑肌肌动蛋白（SMA），然而，在结膜下治疗的家兔角膜中 SMA 肌成纤维细胞的密度显著降低，抑制了肌成纤维细胞的生成[1]。

[1]. M R Santhiago, et al. Monocyte development inhibitor PRM-151 decreases corneal myofibroblast generation in rabbits. Exp Eye Res. 2011 Nov;93(5):786-9.