1387453-03-3
1387453-03-3 structure
- Name: Zinpentraxin alfa
- Chemical Name: Zinpentraxin alfa
- CAS Number: 1387453-03-3
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2023-01-11 18:29:32
- Modify Date: 2024-04-06 13:52:58
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Zinpentraxin alfa (PRM-151) is a recombinant human pentraxin-2, also known as serum amyloid hSAP, a highly conserved serum protein and soluble pattern recognition receptor (PRR) of the innate immune system that regulates monocyte activation and differentiation. Zinpentraxin alfa inhibits the differentiation of circulating monocytes into fibroblasts and pro-fibroblastic macrophages and suppresses myofibroblast production[1].
| Name | Zinpentraxin alfa |
|---|
| Description | Zinpentraxin alfa (PRM-151) is a recombinant human pentraxin-2, also known as serum amyloid hSAP, a highly conserved serum protein and soluble pattern recognition receptor (PRR) of the innate immune system that regulates monocyte activation and differentiation. Zinpentraxin alfa inhibits the differentiation of circulating monocytes into fibroblasts and pro-fibroblastic macrophages and suppresses myofibroblast production[1]. |
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| Related Catalog | |
| In Vivo | Zinpentraxin alfa（PRM-151）（20 mg/mL，局部 30 μL，每天6 次，连续 5 天或 200 μL 结膜下注射，每隔一天，直到第 8 天）通过局部治疗使家兔前角膜基质中出现大量的肌成纤维细胞标志物α平滑肌肌动蛋白（SMA），然而，在结膜下治疗的家兔角膜中 SMA 肌成纤维细胞的密度显著降低，抑制了肌成纤维细胞的生成[1]。 |
| References |
| No Any Chemical & Physical Properties |