DYRKs-IN-2

Names

[ Name ]:
DYRKs-IN-2

Biological Activity

[Description]:

DYRKs-IN-2 (Example 132) is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively. DYRKs-IN-2 has antitumor activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK

[Target]

IC50: 30.6 nM (DYRK1B) and 12.8 nM (DYRK1A)[2]

[In Vitro]

DYRKs-IN-2 (Example 132) has an EC50 of 22.8 nM for SW620 cell line[1].

[References]

[1]. Kevin Anderson, et al. Pyrido pyrimidines. US20120184542A1

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₃₈ClN₉O₃

[ Molecular Weight ]:
632.16

Related Compounds

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