FK 888

Names

[ Name ]:
FK 888

[Synonym ]:
hms3269a13
fk 888

Biological Activity

[Description]:

FK888 is a potent, selective, and high affinity dipeptide NK1 receptor antagonist. FK888 displaces [3H]-SP binding with a Ki value of 0.69 nM and 0.45 microM. FK888 also inhibits SP-induced airway oedema in guinea-pig after both intravenous and oral administration[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[References]

[1]. Fujii T, et al. Pharmacological profile of a high affinity dipeptide NK1 receptor antagonist, FK888. Br J Pharmacol. 1992;107(3):785-789.

Chemical & Physical Properties

[ Density]:
1.26g/cm3

[ Boiling Point ]:
901.9ºC at 760mmHg

[ Molecular Formula ]:
C₃₆H₃₆N₄O₄

[ Molecular Weight ]:
588.70

[ Flash Point ]:
499.2ºC

[ Exact Mass ]:
588.27400

[ PSA ]:
94.88000

[ LogP ]:
4.62180

[ Vapour Pressure ]:
5.08E-35mmHg at 25°C

[ Index of Refraction ]:
1.658

MSDS

Click to get detail MSDS

Related Compounds

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