Hedycoronen A

Names

[ Name ]:
Hedycoronen A

[Synonym ]:
2(5H)-Furanone, 3-[(E)-2-[(1S,4aS,8aS)-decahydro-5,5,8a-trimethyl-2-methylene-1-naphthalenyl]ethenyl]-5-methoxy-
5-Methoxy-3-{(E)-2-[(1S,4aS,8aS)-5,5,8a-trimethyl-2-methylenedecahydro-1-naphthalenyl]vinyl}-2(5H)-furanone

Biological Activity

[Description]:

Hedycoronen A has inhibitory activity on the IL-6, IL-12 p40, and TNF-α production in LPS-Stimulated BMDCs, with IC50s of 9.1 μM, 5.6 μM, and 46.0 μM. Hedycoronen A can be isolated from Hedychium coronarium[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

Research Areas >> Inflammation/Immunology

[References]

[1]. Kiem PV, et al. Labdane-type diterpenoids from the rhizomes of Hedychium coronarium inhibit lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Chem Pharm Bull (Tokyo). 2012;60(2):246-50.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
458.2±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₃₀O₃

[ Molecular Weight ]:
330.46

[ Flash Point ]:
196.6±23.3 °C

[ Exact Mass ]:
330.219482

[ PSA ]:
35.53000

[ LogP ]:
4.90

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.529

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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