Stearyl glycyrrhetinate

Names

[ Name ]:
Stearyl glycyrrhetinate

[Synonym ]:
Olean-12-en-30-oic acid, 3-hydroxy-11-oxo-, octadecyl ester, (3β,5ξ,18α)-
Stearyl glycyrrhetinate
a-Glycyrrhetinic acid stearyl ester
Octadecyl glycyrrhetinate
Olean-12-en-30-oicacid,3b-hydroxy-11-oxo-,octadecyl ester(8CI)
stearyl glycyrrhizinate
n-Octadecyl glycyrrhetinate
Olean-12-en-30-oic acid, 3-hydroxy-11-oxo-, octadecyl ester, (3β)-
stearyl glycyrrhizate
stearyl glycyrrhetate
Octadecyl (3β)-3-hydroxy-11-oxoolean-12-en-30-oate
CO-Grhetinol
Octadecyl (3β,5ξ,18α)-3-hydroxy-11-oxoolean-12-en-30-oate

Biological Activity

[Description]:

Stearyl glycyrrhetinate, a major component in licorice extract, has a MIC against S. aureus strains of more than 256 mg/L. Stearyl glycyrrhetinate has antibacterial effects[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Glycyrrhetinic acid (GRA) and disodium succinoyl glycyrrhetinate (GR-SU) shows strong antibacterial activities compared to the other three agents tested. At a higher concentration (above 2x MIC), GRA and GR-SU shows bactericidal activity, whereas at a concentration of 1x MIC, they showed a bacteriostatic effect[1].

[References]

[1]. Oyama K, et al. Antibacterial Effects of Glycyrrhetinic Acid and Its Derivatives on Staphylococcus aureus. PLoS One. 2016 Nov 7;11(11):e0165831.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
732.5±60.0 °C at 760 mmHg

[ Melting Point ]:
70-77ºC

[ Molecular Formula ]:
C₄₈H₈₂O₄

[ Molecular Weight ]:
723.162

[ Flash Point ]:
198.8±26.4 °C

[ Exact Mass ]:
722.621338

[ PSA ]:
63.60000

[ LogP ]:
16.03

[ Vapour Pressure ]:
0.0±5.4 mmHg at 25°C

[ Index of Refraction ]:
1.525

MSDS

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Safety Information

[ HS Code ]:
2918990090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%