MpsBAY2a

Names

[ Name ]:
MpsBAY2a

[Synonym ]:
MFCD29081183
N-Cyclopropyl-4-[8-(isobutylamino)-6-(5-quinolinyl)imidazo[1,2-a]pyrazin-3-yl]benzamide
Benzamide, N-cyclopropyl-4-[8-[(2-methylpropyl)amino]-6-(5-quinolinyl)imidazo[1,2-a]pyrazin-3-yl]-

Biological Activity

[Description]:

Mps-BAY2a is a monopolar spindle 1 (MPS1) inhibitor with an IC50 of 1 nM against human MPS1. Mps-BAY2a induces mitotic aberrations and apoptosis in cancer cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Cytoskeleton >> Mps1

Signaling Pathways >> Cell Cycle/DNA Damage >> Mps1

[Target]

IC50: 1 nM (human MPS1), 2.6 nM (rat MPS1), 9 nM (mouse MPS1)[1]

[References]

[1]. Jemaà M, et al. Characterization of novel MPS1 inhibitors with preclinical anticancer activity. Cell Death Differ. 2013 Nov;20(11):1532-45.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₂₉H₂₈N₆O

[ Molecular Weight ]:
476.572

[ Exact Mass ]:
476.232452

[ LogP ]:
5.34

[ Index of Refraction ]:
1.716

Related Compounds

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