(R,R)-THC

Names

[ Name ]:
(R,R)-THC

[Synonym ]:
(R,R)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol

Biological Activity

[Description]:

(R,R)-THC is an ERα agonist and an ERβ antagonist, with Kis of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R,R)-THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Research Areas >> Metabolic Disease

[Target]

ERα:9.0 nM (Ki)

ERβ:3.6 nM (Ki)

[References]

[1]. Sun J, et al. Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta. Endocrinology. 1999;140(2):800-804.

Chemical & Physical Properties

[ Density]:
1.21g/cm3

[ Boiling Point ]:
519ºC at 760mmHg

[ Molecular Formula ]:
C₂₂H₂₄O₂

[ Molecular Weight ]:
320.42

[ Flash Point ]:
239.5ºC

[ Exact Mass ]:
320.17800

[ PSA ]:
40.46000

[ LogP ]:
5.17320

[ Vapour Pressure ]:
2.17E-11mmHg at 25°C

[ Index of Refraction ]:
1.65

Safety Information

[ Safety Phrases ]:
S22

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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