Puwainaphycin F

Names

[ Name ]:
Puwainaphycin F

Biological Activity

[Description]:

Puwainaphycin F, a cyanobacterial cyclic lipopeptide, is a moderate cytotoxin isolated from the soil cyanobacterium Cylindrospermum alatosporum C24/89. Puwainaphycin F causes necrotic cell death to mammalian cells via cell membrane permeabilization and subsequent unusual actin relocalization[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

[In Vitro]

Puwainaphycin F has an IC50 of 2.19 μM in HeLa cells[1].

[References]

[1]. Pavel Hrouzek , et al. The cyanobacterial cyclic lipopeptides puwainaphycins F/G are inducing necrosis via cell membrane permeabilization and subsequent unusual actin relocalization. Chem Res Toxicol. 2012 Jun 18;25(6):1203-11.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₃H₈₇N₁₃O₁₅

[ Molecular Weight ]:
1146.34

Related Compounds

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