YW3-56

Names

[ CAS No. ]:
1374311-17-7

[ Name ]:
YW3-56

Biological Activity

[Description]:

YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor, with an IC50 of 1-5 μM for PAD4.

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Protein Arginine Deiminase

Research Areas >> Cancer

[Target]

IC50: 1-5 μM (PAD4)[1].

[In Vitro]

Compared with Cl-amidine, YW3-56 shows >60-fold increase in cell growth inhibition efficacy (IC50 about 2.5 μM) but only 5-fold increase in PAD4 inhibition (IC sub>50 about 1-5 μM). At 2-4 μM concentrations, YW3-56 displays mainly cytostatic effects by slowing cell division, whereas at higher concentrations, it exerts cytotoxic effects by altering cell morphology and killing cells[1].

[References]

[1]. Wang Y, et al. Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and t he mammalian target of rapamycin complex 1 activity. J Biol Chem. 2012 Jul 27;287(31):25941-53.

[Related Small Molecules]

GSK484 | BB-Cl-Amidine | Cl-amidine

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₂ClN₅O₂

[ Molecular Weight ]:
494.03

Related Compounds

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