Cavosonstat

Names

[ Name ]:
Cavosonstat

[Synonym ]:
3-Chloro-4-(6-hydroxy-2-quinolinyl)benzoic acid
O2Z8Q22ZE4
UNII:O2Z8Q22ZE4
Cavosonstat
10452
N91115
Benzoic acid, 3-chloro-4-(6-hydroxy-2-quinolinyl)-

Biological Activity

[Description]:

Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor. Cavosonstat is a CFTR stabilizer, and can be used for cystic fibrosis research[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR

Signaling Pathways >> Metabolic Enzyme/Protease >> GSNOR

Research Areas >> Inflammation/Immunology

[In Vitro]

Cavosonstat (N91115), a CFTR modulator, promotes cystic fibrosis transmembrane conductance regulator (CFTR) maturation and plasma membrane stability, with a mechanism of action complementary to CFTR correctors and potentiators[1].

[References]

[1]. Scott H Donaldson, et al. Pharmacokinetics and safety of cavosonstat (N91115) in healthy and cystic fibrosis adults homozygous for F508DEL-CFTR. J Cyst Fibros. 2017 May;16(3):371-379.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
527.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₀ClNO₃

[ Molecular Weight ]:
299.708

[ Flash Point ]:
272.8±30.1 °C

[ Exact Mass ]:
299.034912

[ LogP ]:
4.28

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.715

Related Compounds

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