1371587-51-7

1371587-51-7 structure

Name: Cavosonstat
Chemical Name: Cavosonstat
CAS Number: 1371587-51-7
Molecular Formula: C₁₆H₁₀ClNO₃
Molecular Weight: 299.708
Create Date: 2018-10-17 10:33:44
Modify Date: 2025-08-27 20:54:15
Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor. Cavosonstat is a CFTR stabilizer, and can be used for cystic fibrosis research[1].

Name	Cavosonstat
Synonyms	3-Chloro-4-(6-hydroxy-2-quinolinyl)benzoic acid O2Z8Q22ZE4 UNII:O2Z8Q22ZE4 Cavosonstat 10452 N91115 Benzoic acid, 3-chloro-4-(6-hydroxy-2-quinolinyl)-

Description	Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor. Cavosonstat is a CFTR stabilizer, and can be used for cystic fibrosis research[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR Signaling Pathways >> Metabolic Enzyme/Protease >> GSNOR Research Areas >> Inflammation/Immunology
In Vitro	Cavosonstat (N91115), a CFTR modulator, promotes cystic fibrosis transmembrane conductance regulator (CFTR) maturation and plasma membrane stability, with a mechanism of action complementary to CFTR correctors and potentiators[1].
References	[1]. Scott H Donaldson, et al. Pharmacokinetics and safety of cavosonstat (N91115) in healthy and cystic fibrosis adults homozygous for F508DEL-CFTR. J Cyst Fibros. 2017 May;16(3):371-379.