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SOLENOPSIN

Names

[ CAS No. ]:
137038-57-4

[ Name ]:
SOLENOPSIN

[Synonym ]:
cis-2-methyl-6-undecylpiperidine
(+/-)-epi-solenopsin A
cis-6-methyl-2-undecanylpiperidine
(-)-Solenopsin A
cis-2-Undecyl-5-methylpiperidine
(+/-)-cis isosolenopsin A
solenopsin
(+/-)-isosolenopsin
(+/-)-isosolenopsin A

Biological Activity

[Description]:

Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 μM .

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Research Areas >> Cardiovascular Disease

[Target]

IC50：10 μM[1].


[References]

[1]. Arbiser JL, et al. Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis. Blood. 2007 Jan 15;109(2):560-5. Epub 2006 Sep 21.


[Related Small Molecules]

SB203580 | MK-2206 2HCl | SC79 | Capivasertib (AZD5363) | Honokiol | AKT inhibitor VIII | GDC-0068 | GSK690693 | Uprosertib | 1,3-Dicaffeoylquinic acid | TIC10 | Triciribine | Perifosine (KRX-0401) | afuresertib | A-443654

Chemical & Physical Properties

[ Molecular Formula ]:
C17H35N

[ Molecular Weight ]:
253.46600

[ Exact Mass ]:
253.27700

[ PSA ]:
12.03000

[ LogP ]:
5.76670

Related Compounds

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