<Suppliers Price>

21-Desacetyl Deflazacort

Names

[ CAS No. ]:
13649-57-5

[ Name ]:
21-Desacetyl Deflazacort

[Synonym ]:
21-desacetyl deflazacort
(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-6b-Glycoloyl-5-hydroxy-4a,6a,8-trimethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]oxazol-2-one
2H-Naphth[2',1':4,5]indeno[1,2-d]oxazol-2-one, 4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-6b-(2-hydroxyacetyl)-4a,6a,8-trimethyl-, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-

Biological Activity

[Description]:

21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[References]

[1]. Möllmann H, et al. Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone. Pharm Res. 1995 Jul;12(7):1096-100.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
585.0±50.0 °C at 760 mmHg

[ Melting Point ]:
228-230 °C

[ Molecular Formula ]:
C23H29NO5

[ Molecular Weight ]:
399.48

[ Flash Point ]:
307.6±30.1 °C

[ Exact Mass ]:
399.204559

[ PSA ]:
96.19000

[ LogP ]:
0.90

[ Vapour Pressure ]:
0.0±3.7 mmHg at 25°C

[ Index of Refraction ]:
1.690

[ Storage condition ]:
2-8°C

Synthetic Route

Precursor & DownStream


Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.