N-Palmitoyl Dopamine

Names

[ Name ]:
N-Palmitoyl Dopamine

[Synonym ]:
Palmitoyl dopamine
HMS3268B22
N-[2-(3,4-Dihydroxyphenyl)ethyl]hexadecanamide
Hexadecanamide, N-[2-(3,4-dihydroxyphenyl)ethyl]-
BML3-G01
N-Palmitoyl Dopamine
PALDA

Biological Activity

[Description]:

N-Palmitoyl dopamine (PALDA) is a endogenous, long-chain, linear fatty acid dopamide, which is inactive on TRPV1. N-Palmitoyl dopamine displays 'entourage' effects on endovanilloids N-arachidonoyl-dopamine (NADA) and anandamide[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

PALDA (0.1-10 μM), the EC50 of N-arachidonoyl-dopamine (NADA) is lowered from approximately 90 to approximately 30 nM. The effect on intracellular Ca2+ by another endovanilloid, N-arachidonoyl-ethanolamine (anandamide, 50 nM), is also enhanced dose-dependently by PALDA. PALDA also acted in synergy with low pH (6.0-6.7) to enhance intracellular Ca2+ via TRPV1[1].

[References]

[1]. Luciano De Petrocellis, et al. Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. Br J Pharmacol. 2004 Sep;143(2):251-6.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
589.5±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₄₁NO₃

[ Molecular Weight ]:
391.587

[ Flash Point ]:
310.3±27.3 °C

[ Exact Mass ]:
391.308655

[ PSA ]:
69.56000

[ LogP ]:
7.22

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.515

Related Compounds

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