PI3K-IN-31

Names

[ CAS No. ]:
1359956-12-9

[ Name ]:
PI3K-IN-31

Biological Activity

[Description]:

PI3K-IN-31 (Compound 6b) is a potent PI3K inhibitor with IC50s of 3.7 nM, 74 nM, 14.6 nM, and 9.9 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively. PI3K-IN-31 has anticancer effects[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[Target]

PI3Kα:3.7 nM (IC50)

PI3Kδ:9.9 nM (IC50)

PI3Kγ:14.6 nM (IC50)

PI3Kβ:74 nM (IC50)


[References]

[1]. Marcian E Van Dort, et al. Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors. Eur J Med Chem. 2022 Feb 5;229:113996.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H23F2N7O3

[ Molecular Weight ]:
435.43

Related Compounds