BRD5529

Names

[ Name ]:
BRD5529

Biological Activity

[Description]:

BRD5529 is a selective CARD9-E3 ubiquitin ligase TRIM62 protein-protein interaction inhibitor with an IC50 of 8.6 μM. BRD5529 directly and selectively binds CARD9, disrupts TRIM62 recruitment, inhibits TRIM62-mediated ubiquitinylation and activation of CARD9, and demonstrates cellular activity and selectivity in CARD9-dependent pathways[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

[Target]

IC50: 8.6 μM (CARD9-E3 ubiquitin ligase TRIM62)[1]

[References]

[1]. Leshchiner ES, et al. Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatorybowel disease. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11392-11397.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₃₁N₅O₄

[ Molecular Weight ]:
465.54

Related Compounds

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