UNC119

UNC119-Src interaction inhibitor 3 is a potent, specific small molecule inhibitor of UNC119-Src interaction with IC50 of 12 nM for displacement of the Src peptide from UNC119A; selectivity released all N-myristoylated peptides from UNC119, but not the farnesyl-protein binding proteins PDE6d, AIPL1 and calmodulin; binds to UNC119 in cells (Kd=71.8 nM), and induces redistribution of Src to endomembranes and reduction of activating Src autophosphorylation on Y419; UNC119 inhibition in Src-dependent colorectal cancer cells results in the specific reduction of cell growth and clonogenic potential.

References 1. Garivet G, et al. Cell Chem Biol. 2019 Mar 13. pii: S2451-9456(19)30074-1. View Related Products by Target Src