1358350-63-6
1358350-63-6 structure
- Name: UNC119
- Chemical Name: UNC119-Src interaction inhibitor 3
- CAS Number: 1358350-63-6
- Molecular Formula: C22H26N4O4S2
- Molecular Weight: 474.594
- Create Date: 2020-01-11 16:17:55
- Modify Date: 2023-02-13 19:19:15
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UNC119-Src interaction inhibitor 3 is a potent, specific small molecule inhibitor of UNC119-Src interaction with IC50 of 12 nM for displacement of the Src peptide from UNC119A; selectivity released all N-myristoylated peptides from UNC119, but not the farnesyl-protein binding proteins PDE6d, AIPL1 and calmodulin; binds to UNC119 in cells (Kd=71.8 nM), and induces redistribution of Src to endomembranes and reduction of activating Src autophosphorylation on Y419; UNC119 inhibition in Src-dependent colorectal cancer cells results in the specific reduction of cell growth and clonogenic potential.
| Name | UNC119-Src interaction inhibitor 3 |
|---|
| Description | UNC119-Src interaction inhibitor 3 is a potent, specific small molecule inhibitor of UNC119-Src interaction with IC50 of 12 nM for displacement of the Src peptide from UNC119A; selectivity released all N-myristoylated peptides from UNC119, but not the farnesyl-protein binding proteins PDE6d, AIPL1 and calmodulin; binds to UNC119 in cells (Kd=71.8 nM), and induces redistribution of Src to endomembranes and reduction of activating Src autophosphorylation on Y419; UNC119 inhibition in Src-dependent colorectal cancer cells results in the specific reduction of cell growth and clonogenic potential. |
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| References | References 1. Garivet G, et al. Cell Chem Biol. 2019 Mar 13. pii: S2451-9456(19)30074-1. View Related Products by Target Src |
| Molecular Formula | C22H26N4O4S2 |
|---|---|
| Molecular Weight | 474.594 |