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HG-14-10-04

Names

[ CAS No. ]:
1356962-34-9

[ Name ]:
HG-14-10-04

[Synonym ]:
HG-14-10-04

Biological Activity

[Description]:

HG-14-10-04 is a potent and specific ALK inhibitor with IC50 of 20 nM.IC50 value: 20 nMTarget: ALKMore information can be found in the following Patent, Example 10Preparation of substituted pyrimidinamines as ALK kinase inhibitorsBy Aquila, Brian; Kamhi, Victor; Peng, Bo; Pontz, Timothy; Saeh, Jamal Carlos; Thakur, Kumar; Yang, Bin From U.S. Pat. Appl. Publ. (2012), US 20120028924 A1 20120202.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
Research Areas >> Cancer

[References]

[1]. U.S. Pat. Appl. Publ. (2012), US 20120028924 A1


[Related Small Molecules]

Brigatinib | lorlatinib | Alectinib (CH5424802) | Entrectinib | TAE684(NVP-TAE684) | AZD-3463 | Repotrectinib | Ensartinib | AP26113 | K 02288 | ASP3026 | CEP-37440 | GSK1838705A | Belizatinib

Chemical & Physical Properties

[ Molecular Formula ]:
C29H34ClN7O

[ Molecular Weight ]:
532.08000

[ Exact Mass ]:
531.25100

[ PSA ]:
72.55000

[ LogP ]:
5.26050

[ Storage condition ]:
2-8℃

Related Compounds