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ASP3026

Names

[ CAS No. ]:
1097917-15-1

[ Name ]:
ASP3026

[Synonym ]:
N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine
cc-325
QCR-144
N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine
ASP 3026
N-[2-(isopropylsulfonyl)phenyl]-N'-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-1,3,5-triazine-2,4-diamine
1,3,5-Triazine-2,4-diamine, N-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N-[2-[(1-methylethyl)sulfonyl]phenyl]-
CS-0787
UNII-HP4L6MXF10
N-[2-(Isopropylsulfonyl)phenyl]-N'-{2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl}-1,3,5-triazine-2,4-diamine
ASP3026

Biological Activity

[Description]:

ASP3026 is a novel and selective inhibitor for ALK (anaplastic lymphoma kinase) with IC50 of 3.5 nM.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
Research Areas >> Cancer

[References]

[1]. Sadao Kuromitsu, et al. AACR 102nd Annual Meeting, 2011.


[Related Small Molecules]

Brigatinib | lorlatinib | Alectinib (CH5424802) | Entrectinib | TAE684(NVP-TAE684) | AZD-3463 | Repotrectinib | Ensartinib | AP26113 | K 02288 | CEP-37440 | GSK1838705A | Belizatinib | X-396 hydrochloride

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
794.3±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H40N8O3S

[ Molecular Weight ]:
580.745

[ Flash Point ]:
434.2±35.7 °C

[ Exact Mass ]:
580.294434

[ PSA ]:
127.43000

[ LogP ]:
1.01

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.620

[ Storage condition ]:
-20°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds