GS 462808
Names
[ CAS No. ]:
1354198-41-6
[ Name ]:
GS 462808
Biological Activity
[Description]:
GS 462808 is a potent Late INa current inhibitor with IC50 of 1.33 uM; has lower brain penetration and serendipitously lower activity at the brain isoforms, and improved CNS window (>20 rat and dog) relative to GS-458967; shows improved anti-ischemic potency relative to ranolazine.
[References]
References 1. Koltun DO, et al. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3207-11. View Related Products by Target Sodium Channel
Chemical & Physical Properties
[ Molecular Formula ]:
C17H12F3N5O3
[ Molecular Weight ]:
391.31