clathrodin

Names

[ Name ]:
clathrodin

[Synonym ]:
Clathrodine
Clathrodin
N-(3-(2-Imino-2,3-dihydro-1H-imidazol-4-yl)-2-propenyl)-1H-pyrrole-2-carboxamide
1H-Pyrrole-2-carboxamide,N-(3-(2-amino-1H-imidazol-4-yl)-2-propenyl)-,(E)

Biological Activity

[Description]:

Clathrodin is a marine alkaloid that can be isolated from sponges of the genus, Agelas. Clathrodin is a modulator of voltage-gated sodium (NaV) channels. Clathrodin is a sodium channel neurotoxin influencing sodium channel ionic conductance[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Neurological Disease

[References]

[1]. Rentas AL, et al. Effect of alkaloid toxins from tropical marine sponges on membrane sodium currents. Toxicon. 1995 Apr;33(4):491-7.

Chemical & Physical Properties

[ Density]:
1.382g/cm3

[ Molecular Formula ]:
C₁₁H₁₃N₅O

[ Molecular Weight ]:
231.25400

[ Exact Mass ]:
231.11200

[ PSA ]:
100.32000

[ LogP ]:
1.08420

[ Index of Refraction ]:
1.726

Related Compounds

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