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DBCO-NHS ester

Names

[ CAS No. ]:
1353016-71-3

[ Name ]:
DBCO-NHS ester

[Synonym ]:
DBCO-NHS ester
Dibenzylcyclooctyne-NHS ester
Dibenzocyclooctyne-N-hydroxysuccinimidyl ester
DBCO-succinyl N-hydroxysuccinimidyl ester
2,5-dioxopyrrolidin-1-yl 4-(11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl)-4-oxobutanoate
2,5-dioxopyrrolidin-1-yl 4-(didehydrodibenzo[b,f]azocin-5(6H)-yl)-4-oxobutanoate

Biological Activity

[Description]:

DBCO-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Method for identifying potential drug target protein useful for development of antibody drug, and method for producing antibody directed against target protein. WO2018151301A1.

Chemical & Physical Properties

[ Density]:
1.43±0.1 g/cm3

[ Boiling Point ]:
670.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H18N2O5

[ Molecular Weight ]:
402.39900

[ Exact Mass ]:
402.12200

[ PSA ]:
83.99000

[ LogP ]:
2.32330

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds