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T338C Src-IN-2

Names

[ CAS No. ]:
1351927-00-8

[ Name ]:
T338C Src-IN-2

[Synonym ]:
1-{3-[(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)methyl]phenyl}-2-fluoroethanone
Ethanone, 1-[3-[[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]methyl]phenyl]-2-fluoro-

Biological Activity

[Description]:

T338C Src-IN-2 is a potent mutant c-Src T338C kinase inhibitor with IC50 of 317 nM; also inhibits T338C/V323A and T338C/V323S with IC50 of 57 nM/19 nM.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src
Research Areas >> Cancer

[References]

[1]. Garske AL, et al. Chemical genetic strategy for targeting protein kinases based on covalent complementarity. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15046-52.


[Related Small Molecules]

Saracatinib | PP2 (AG 1879) | A 419259 trihydrochloride | DCC-2036 (Rebastinib) | SU6656 | 1-Naphthyl PP1 | WH-4-023 | Pelitinib | Src Inhibitor-1 | ENMD-2076 | TC-S 7003 | PD173955 | TG 100572 (Hydrochloride) | XL228 | A-196

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
540.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H18FN5O

[ Molecular Weight ]:
327.356

[ Flash Point ]:
280.8±30.1 °C

[ Exact Mass ]:
327.149536

[ LogP ]:
1.54

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.657

[ Storage condition ]:
2-8℃

Related Compounds

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