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Taccalonolide AJ

Names

[ CAS No. ]:
1349904-82-0

[ Name ]:
Taccalonolide AJ

Biological Activity

[Description]:

Taccalonolide AJ is a semi-synthesis compound with cellular microtubule stabilizing activity. Taccalonolide AJ exhibits high potency antiproliferative activity against cancer cells, with an IC50 of 4.2 nM for HeLa cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

microtubule[1]


[References]

[1]. Li J, et al. Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers. J Am Chem Soc. 2011 Nov 30;133(47):19064-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C34H44O14

[ Molecular Weight ]:
676.70500

[ Exact Mass ]:
676.27300

[ PSA ]:
208.02000

[ LogP ]:
0.05300

[ Storage condition ]:
2-8℃

Related Compounds