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Debutyldronedarone D6 hydrochloride

Names

[ CAS No. ]:
1346598-70-6

[ Name ]:
Debutyldronedarone D6 hydrochloride

[Synonym ]:
Desbutyl Dronedarone-d4 Hydrochloride
N-[2-Butyl-3-[4-[3-(butylamino)propoxybenzoyl]-5-benzofuranyl]-methanesulfonamide-d4 Hydrochloride

Biological Activity

[Description]:

Debutyldronedarone D6 hydrochloride (SR35021 D6 hydrochloride) is deuterium labeled Debutyldronedarone. Debutyldronedarone is a major circulating active metabolite of dronedarone (HY-A0016) in humans. Debutyldronedarone exhibits a potency that is 1/10 to 1/3 of that of the parent agent[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[References]

[1]. Cen Xie, et al. Simultaneous determination of dronedarone and its active metabolite debutyldronedarone in human plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study.J Chromatogr B Analyt Technol Biomed Life Sci

[2]. Marina Santos, et al.Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride. J Pharm Biomed Anal. 2015 Oct 10;114:441-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H31ClD6N2O5S

[ Molecular Weight ]:
543.14800

[ Exact Mass ]:
542.24900

[ PSA ]:
106.02000

[ LogP ]:
7.88320

Related Compounds