MC-Val-Ala-PBD

Names

[ Name ]:
MC-Val-Ala-PBD

Biological Activity

[Description]:

MC-Val-Ala-PBD is a drug-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Pyrrolobenzodiazepines

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Jeffrey SC, et al. A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology. Bioconjug Chem. 2013 Jul 17;24(7):1256-63.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₀H₆₄N₈O₁₂

[ Molecular Weight ]:
1089.20000

[ Exact Mass ]:
1088.46000

[ PSA ]:
236.17000

[ LogP ]:
7.11240

Related Compounds

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