Quilseconazole

Names

[ Name ]:
Quilseconazole

Biological Activity

[Description]:

Quilseconazole (VT-1129) is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor, binds tightly to cryptococcal CYP51, but weakly inhibits humans CYP450 enzymes[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Signaling Pathways >> Anti-infection >> Fungal

[Target]

Fungal, Cyp51[1]

[References]

[1]. Lockhart SR, et al. The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2528-31.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₁₄F₇N₅O₂

[ Molecular Weight ]:
513.37

Related Compounds

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