(S)-4CPG

Names

[ Name ]:
(S)-4CPG

Biological Activity

[Description]:

(S)-4CPG ((S)-4-Carboxyphenylglycine) is a potent mGluR2 agonist. (S)-4CPG reduces hyperalgesia and allodynia associated with sciatic nerve contraction injury in rats. (S)-4CPG can be used in research on neurological diseases[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[References]

[1]. Hayashi Y, et al. Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. J Neurosci. 1994 May;14(5 Pt 2):3370-7.

[2]. Fisher K, et al. Intrathecal administration of the mGluR compound, (S)-4CPG, attenuates hyperalgesia and allodynia associated with sciatic nerve constriction injury in rats. Pain. 1998 Jul;77(1):59-66.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₉NO₄

[ Molecular Weight ]:
195.17

[ Exact Mass ]:
195.05300

[ PSA ]:
100.62000

[ LogP ]:
1.16950

Related Compounds

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