AG 556

Names

[ CAS No. ]:
133550-41-1

[ Name ]:
AG 556

[Synonym ]:
Tyrphostin B 56
AG 556
TYRPHOSTIN AG 556

Biological Activity

[Description]:

(E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production[1][2].

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

Research Areas >> Inflammation/Immunology

[References]

[1]. Gazit A, et al. Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J Med Chem. 1991 Jun;34(6):1896-907.

[2]. George J, et al. Tyrphostin AG-556 reduces myocardial infarct size and improves cardiac performance in the rat. Exp Mol Pathol. 2003 Jun;74(3):314-8.

Chemical & Physical Properties

[ Density]:
1.247g/cm3

[ Boiling Point ]:
636.1ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₂₀N₂O₃

[ Molecular Weight ]:
336.38400

[ Flash Point ]:
338.5ºC

[ Exact Mass ]:
336.14700

[ PSA ]:
93.35000

[ LogP ]:
3.53478

[ Vapour Pressure ]:
8.95E-17mmHg at 25°C

[ Index of Refraction ]:
1.638

[ Storage condition ]:
-20°C

Safety Information

[ Safety Phrases ]:
S22-S24/25

Related Compounds

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