Zidovudine O-β-D-glucuronide sodium

Names

[ Name ]:
Zidovudine O-β-D-glucuronide sodium

Biological Activity

[Description]:

Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection[1][2].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Fayz S, et, al. Zidovudine azido-reductase in human liver microsomes: activation by ethacrynic acid, dipyridamole, and indomethacin and inhibition by human immunodeficiency virus protease inhibitors. Antimicrob Agents Chemother. 1998 Jul;42(7):1654-8.

[2]. Bélanger AS, et, al. Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine. Drug Metab Dispos. 2009 Sep;37(9):1793-6.

Chemical & Physical Properties

[ Melting Point ]:
158-163ºC

[ Molecular Formula ]:
C₁₆H₂₀N₅NaO₁₀

[ Molecular Weight ]:
465.34700

[ Exact Mass ]:
465.11100

[ PSA ]:
208.09000

[ Storage condition ]:
-20°C Freezer, Under Inert Atmosphere

Related Compounds

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