<Suppliers Price>

Itacitinib

Names

[ CAS No. ]:
1334298-90-6

[ Name ]:
Itacitinib

[Synonym ]:
2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile
{1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile
{1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin3-yl}acetonitrile
Itacitinib

Biological Activity

[Description]:

Itacitinib is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis.

[Related Catalog]:

Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Research Areas >> Cancer

[Target]

JAK1


[In Vitro]

Itacitinib (INCB039110) is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2. Itacitinib is used in the research of myelofibrosis[1].

[References]

[1]. Mascarenhas JO, et al. Primary analysis of a phase II open-label trial of INCB039110, a selective JAK1 inhibitor, in patients with myelofibrosis. Haematologica. 2017 Feb;102(2):327-335.


[Related Small Molecules]

Baricitinib | Upadacitinib | Pacritinib | CYT387 | AZD1480 | Fedratinib(SAR302503,TG101348) | WP1066 | CHZ868 | AT9283 | GLPG0634 | cerdulatinib | LY2784544 | SB1317 | Peficitinib | Pyridone 6

Chemical & Physical Properties

[ Density]:
1.57±0.1 g/cm3(Predicted)

[ Molecular Formula ]:
C26H23F4N9O

[ Molecular Weight ]:
553.51400

[ Exact Mass ]:
553.19600

[ PSA ]:
119.62000

[ LogP ]:
3.47948

[ Storage condition ]:
-20℃

Safety Information

[ Hazard Codes ]:
N

Related Compounds