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Itacitinib adipate

Names

[ CAS No. ]:
1334302-63-4

[ Name ]:
Itacitinib adipate

[Synonym ]:
Itacitinib adipate
Hexanedioic acid - (1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]-4-piperidinyl}-3-[4-(1H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidinyl)acetonitrile (1:1)
UNII-XZG407XE0Y
INCB039110 adipate
(1-{1-[3-fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl)acetonitrile monohexanedioate
Hexanedioic acid, compd. with 1-[1-[[3-fluoro-2-(trifluoromethyl)-4-pyridinyl]carbonyl]-4-piperidinyl]-3-[4-(1H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile (1:1)

Biological Activity

[Description]:

Itacitinib adipate is a selective JAK1 inhibitor which has been tested for efficacy and safety in a phase II trial in myelofibrosis.

[Related Catalog]:

Research Areas >> Cancer

[Target]

JAK1


[References]

[1]. Griesshammer M, et al. The BCR-ABL1-negative myeloproliferative neoplasms: a review of JAK inhibitors in the therapeutic armamentarium. Expert Opin Pharmacother. 2017 Dec;18(18):1929-1938.


[Related Small Molecules]

Baricitinib | Upadacitinib | Pacritinib | CYT387 | AZD1480 | Fedratinib(SAR302503,TG101348) | WP1066 | CHZ868 | AT9283 | GLPG0634 | Itacitinib | cerdulatinib | LY2784544 | SB1317 | Peficitinib

Chemical & Physical Properties

[ Molecular Formula ]:
C32H33F4N9O5

[ Molecular Weight ]:
699.655

[ Exact Mass ]:
699.254089

[ Storage condition ]:
2-8℃

Related Compounds