Cdc7 inhibitor 7c

Names

[ Name ]:
Cdc7 inhibitor 7c

[Synonym ]:
6-(3-Methyl-1H-pyrazol-4-yl)-2-(1-pyrrolidinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one
Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(3-methyl-1H-pyrazol-4-yl)-2-(1-pyrrolidinylmethyl)-

Biological Activity

[Description]:

A highly potent, selective and time-dependent Cdc7 kinase inhibitor with IC50 of 0.7 nM with slow dissociation property, with 200-fold and >14,000-fold selectivity over CDK2 and ROCK1, respectively; exhibits significant time-dependent Cdc7 inhibition with slow dissociation kinetics, cellular pharmacodynamic (PD) effects, and COLO205 growth inhibition.

[References]

References 1. Kurasawa O, et al. Bioorg Med Chem. 2017 Jul 15;25(14):3658-3670. View Related Products by Target Cyclin-dependent Kinase (CDK)

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C₁₅H₁₇N₅OS

[ Molecular Weight ]:
315.393

[ Exact Mass ]:
315.115387

[ LogP ]:
1.71

[ Index of Refraction ]:
1.805

Related Compounds

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