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Nimesulide D5

Names

[ CAS No. ]:
1330180-22-7

[ Name ]:
Nimesulide D5

Biological Activity

[Description]:

Nimesulide D5 is a deuterium labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-2:0.07-70 μM (IC50)


[References]

[1]. Vago T, et al. Effect of nimesulide action time dependence on selectivity towards prostaglandin G/H synthase/cyclooxygenase activity. Arzneimittelforschung. 1995 Oct;45(10):1096-8.

[2]. Werner MF, et al. Nimesulide-induced antipyresis in rats involves both cyclooxygenase-dependent and independent mechanisms. Eur J Pharmacol. 2006 Aug 14;543(1-3):181-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C13H7D5N2O5S

[ Molecular Weight ]:
313.34

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds