PD 81,723
Names
[ CAS No. ]:
132861-87-1
[ Name ]:
PD 81,723
[Synonym ]:
(2-Amino-4,5-dimethylthiophen-3-yl)(3-(trifluoromethyl)phenyl)methanone
Tocris-1363
PD-81,723
(2-Amino-4,5-dimethyl-3-thienyl)-[3-(trifluoromethyl)phenyl]methanone
Chemical & Physical Properties
[ Density]:
1.328g/cm3
[ Boiling Point ]:
411.7ºC at 760 mmHg
[ Molecular Formula ]:
C14H12F3NOS
[ Molecular Weight ]:
299.31100
[ Flash Point ]:
202.8ºC
[ Exact Mass ]:
299.05900
[ PSA ]:
71.33000
[ LogP ]:
4.77810
[ Vapour Pressure ]:
5.48E-07mmHg at 25°C
[ Index of Refraction ]:
1.563
MSDS
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
[ HS Code ]:
2934999090
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
J. Mol. Cell. Cardiol. 31(1) , 123-34, (1999)
The aim of this study was to determine whether endogenous adenosine has antiarrhythmic effects on ischemia-induced ventricular tachyarrhythmias. We therefore modulated the effect of endogenous adenosi...
A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury.Am. J. Physiol. Renal Physiol. 303(5) , F721-32, (2012)
Activation of A(1) adenosine receptors (ARs) protects against renal ischemia-reperfusion (I/R) injury by reducing necrosis, apoptosis, and inflammation. However, extrarenal side effects (bradycardia, ...
Novel mitogenic effect of adenosine on coronary artery smooth muscle cells: role for the A1 adenosine receptor.Circ. Res. 96(9) , 982-90, (2005)
Adenosine is a vascular endothelial cell mitogen, but anti-mitogenic for aortic smooth muscle cells and fibroblasts when acting via the A2B adenosine receptor. However, we show that adenosine increase...