N-(1-OXO-4Z,7Z,10Z,13Z,16Z,19Z-DOCOSAHEXAENYL)-GLYCINE

Names

[ Name ]:
N-(1-OXO-4Z,7Z,10Z,13Z,16Z,19Z-DOCOSAHEXAENYL)-GLYCINE

[Synonym ]:
Glycine, N-[(4Z,7Z,10Z,13Z,16Z,19Z)-1-oxo-4,7,10,13,16,19-docosahexaen-1-yl]-
N-[(4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoyl]glycine

Biological Activity

[Description]:

Docosahexaenoyl glycine is a PUFA analogue. Docosahexaenoyl glycine has activating effects on IKs?channels?and restore the function of IKs?channels with LQT1 mutation[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

IC50: IKs?Channel[1]

[References]

[1]. Mark A Skarsfeldt, et al. Polyunsaturated fatty acid-derived IKs channel activators shorten the QT interval ex-vivo and in-vivo. Acta Physiol (Oxf). 2020 Aug;229(4):e13471.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
582.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₃₅NO₃

[ Molecular Weight ]:
385.54

[ Flash Point ]:
305.9±30.1 °C

[ Exact Mass ]:
385.261688

[ PSA ]:
66.40000

[ LogP ]:
5.65

[ Vapour Pressure ]:
0.0±3.5 mmHg at 25°C

[ Index of Refraction ]:
1.526

Related Compounds

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