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Glufosfamide

Names

[ CAS No. ]:
132682-98-5

[ Name ]:
Glufosfamide

[Synonym ]:
β-D-glucosyl-ifosfamide mustard
glc-IPM
β-D-Glucopyranose, 1-O-[bis[(2-chloroethyl)amino]phosphinyl]-
UNII-1W5N8SZD9A
b-D-Glucopyranose 1-(N,N'-Bis(2-chloroethyl)phosphorodiamidate)
Glucosylifostamide mustard
1-O-{Bis[(2-chloroethyl)amino]phosphoryl}-β-D-glucopyranose
Glufosfamide
Glucosyl-ifosfamide mustard

Biological Activity

[Description]:

Glufosfamide is a novel alkylating agent in which the active metabolite of isophosphoramide mustard is glycosidically linked to β-D-glucose.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Cancer

[References]

[1]. DollnerR, et al. Ex vivo responsiveness of head and neck squamous cell carcinoma to glufosfamide, a novelalkylating agent. Anticancer Res. 2004 Sep-Oct;24(5A):2947-51.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
569.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H21Cl2N2O7P

[ Molecular Weight ]:
383.163

[ Flash Point ]:
298.5±32.9 °C

[ Exact Mass ]:
382.046356

[ PSA ]:
150.32000

[ LogP ]:
-1.07

[ Vapour Pressure ]:
0.0±3.6 mmHg at 25°C

[ Index of Refraction ]:
1.563

Synthetic Route

Click to get detail synthetic route