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Urea,N,N'-dimethyl-N'-nitroso-

Names

[ CAS No. ]:
13256-32-1

[ Name ]:
Urea,N,N'-dimethyl-N'-nitroso-

[Synonym ]:
N,N'-Dimethylnitrosourea
1,3 dimethyl 1 nitrosourea
N-nitroso-1,3-dimethylurea
Dimethylnitrosourea
1,3-Dimethylnitrosourea
N-nitroso-N,N'-dimethylurea
1,3-Dimethyl-N-nitrosourea
1,2-Dimethyl-1-nitrosourea
Nitrosodimethylurea
N,N'-Dimethyl-N-nitrosourea
N-Nitrosodimethylurea

Chemical & Physical Properties

[ Density]:
1.25g/cm3

[ Molecular Formula ]:
C3H7N3O2

[ Molecular Weight ]:
117.10700

[ Exact Mass ]:
117.05400

[ PSA ]:
61.77000

[ LogP ]:
0.32990

[ Index of Refraction ]:
1.505

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YT0350000
CHEMICAL NAME :
Urea, 1,3-dimethyl-1-nitroso-
CAS REGISTRY NUMBER :
13256-32-1
BEILSTEIN REFERENCE NO. :
1756842
LAST UPDATED :
199612
DATA ITEMS CITED :
22
MOLECULAR FORMULA :
C3-H7-N3-O2
MOLECULAR WEIGHT :
117.13
WISWESSER LINE NOTATION :
ONN1&VM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1300 mg/kg/65W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors Peripheral Nerve and Sensation - peripheral nerve tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
836 mg/kg/20W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Brain and Coverings - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
660 mg/kg/66W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors Peripheral Nerve and Sensation - peripheral nerve tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
720 mg/kg/9W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
680 mg/kg/17W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
56222 mg/kg/30W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
20 mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
DOSE :
10 mg/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
DOSE :
50 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
DNA inhibition

MUTATION DATA

TYPE OF TEST :
Host-mediated assay
TEST SYSTEM :
Rodent - mouse Ascites tumor
DOSE/DURATION :
100 mg/kg
REFERENCE :
EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 8(3),70,1986

Precursor & DownStream


Related Compounds