CATPB

Names

[ Name ]:
CATPB

[Synonym ]:
(3S)-3-{(Z)-[2-(3-Chlorophenyl)-1-hydroxyethylidene]amino}-4-[4-(trifluoromethyl)phenyl]butanoic acid
(S)-3-(2-(3-Chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid
CATPB
Benzenebutanoic acid, β-[[(1Z)-2-(3-chlorophenyl)-1-hydroxyethylidene]amino]-4-(trifluoromethyl)-, (βS)-

Biological Activity

[Description]:

CATPB is a potent, selective free fatty acid receptor 2 (FFA2R/GPR43) antagonist[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[Target]

FFA2R(GPR43)[1]

[In Vitro]

CATPB inhibits the transient rise in intracellular Ca2+ induced in neutrophils by acetate or Cmp1 (FFAR2 agonist)[1]. CATPB inhibits Cmp1-induced NADPH oxidase activity[1].

[References]

[1]. Lena Björkman, et al. The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment. Mol Cell Biol. 2016 Sep 26;36(20):2583-95.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
531.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₇ClF₃NO₃

[ Molecular Weight ]:
399.79

[ Flash Point ]:
275.2±32.9 °C

[ Exact Mass ]:
399.084900

[ LogP ]:
4.92

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.546

Related Compounds

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