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Chrodrimanin B

Names

[ CAS No. ]:
132196-54-4

[ Name ]:
Chrodrimanin B

[Synonym ]:
(-)-Chrodrimanin B
chrodrimanin B
(1R,2R,7aR,8S,9aR,13aS,13bS)-5,8-Dihydroxy-2,7a,10,10,13a-pentamethyl-4,11-dioxo-1,7a,8,9,9a,10,11,13a,13b,14-decahydro-2H,4H-benzo[a]pyrano[3,4-j]xanthen-1-yl acetate
2H,4H-Benzo[a]pyrano[3,4-j]xanthene-4,11(7aH)-dione, 1-(acetyloxy)-1,8,9,9a,10,13a,13b,14-octahydro-5,8-dihydroxy-2,7a,10,10,13a-pentamethyl-, (1R,2R,7aR,8S,9aR,13aS,13bS)-

Biological Activity

[Description]:

Chrodrimanin B, a metabolite of a fungal, is a potent, non-open-channel-blocking antagonist on B. mori GABAR RDL with an IC50 of 1.13 nM. Chrodrimanin B attenuates the peak current amplitude of the GABA response of RDL with an IC50 of 1.66 nM. Chrodrimanin B, a meroterpenoid, shows insecticidal activity[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[In Vitro]

Chrodrimanin B exhibits much weaker blocking action on human α1β2γ2 GABAR compared to RDL (IC50=1.48 μM)[1]. Chrodrimanin B shows competitive actions at low concentrations and non-competitive actions at higher concentrations on B. mori GABAR RDL[1].

[References]

[1]. Yan Xu, et al. Meroterpenoid Chrodrimanins Are Selective and Potent Blockers of Insect GABA-Gated Chloride Channels. PLoS One. 2015 Apr 22;10(4):e0122629.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
663.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H32O8

[ Molecular Weight ]:
484.538

[ Flash Point ]:
221.1±25.0 °C

[ Exact Mass ]:
484.209717

[ LogP ]:
2.97

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.614

Related Compounds