Trypanothione synthetase-IN-3

Names

[ CAS No. ]:
1314875-96-1

[ Name ]:
Trypanothione synthetase-IN-3

Biological Activity

[Description]:

Trypanothione synthetase-IN-3 is a noncompetitive mixed hyperbolic Trypanothione synthetase (TryS) inhibitor (Ki: 0.8 μM). Trypanothione synthetase-IN-3 can be used in the study of parasites, such as L. infantum[1].

[Related Catalog]:

Research Areas >> Infection

[Target]

Trypanothione synthetase (TryS)[1]


[In Vitro]

Trypanothione synthetase-IN-3 (30 min) displays noncompetitive inhibitory behavior against Li TryS with IC50 values of 2 μM -5.6 μM (determined by various substrates)[1]. Trypanothione synthetase-IN-3 (24 h) inhibits proliferation of L. infantum axenic amastigotes with an EC50 value of 43.7 μM[1].

[References]

[1]. Mercedes Alcón-Calderón, et al. Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library. European Journal of Medicinal Chemistry, 2022, 114675.

Chemical & Physical Properties

[ Molecular Formula ]:
C68H54O43

[ Molecular Weight ]:
1559.13

Related Compounds