JHDM-IN-1

Names

[ Name ]:
JHDM-IN-1

Biological Activity

[Description]:

JHDM-IN-1 (Compound 1) is a Jumonji C domain-containing HDMs (JHDM) inhibitor with IC50s of 3.4, 4.3, 5.9, 10 and 43 μM against JMJD2C, JMJD2A, JMJD2E, PHF8 and JMJD3, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Demethylase

[Target]

IC50: 3.4 μM (JMJD2C), 4.3 μM (JMJD2A), 5.9 μM (JMJD2E), 10 μM (PHF8), 22 μM (FIH), 31 μM (PHD3), 43 μM (JMJD3), 54 μM (PHD1), 83 μM (PHD2), 620 μM (LSD1)[1]

[In Vitro]

JHDM-IN-1 (Compound 1) 抑制 FIH、PHD3、PHD1、PHD2 和 LSD1 的 IC50 分别为 22、31、54、83 和 620 μM[1]。 JHDM-IN-1 (0-100 μM) 处理 48 h 后对 KYSE150 细胞生长无抑制作用[1]。

[References]

[1]. Luo X, et al. A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases. J Am Chem Soc. 2011 Jun 22;133(24):9451-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₉N₃O₆

[ Molecular Weight ]:
491.54

Related Compounds

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