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Sephin-1

Names

[ CAS No. ]:
13098-73-2

[ Name ]:
Sephin-1

[Synonym ]:
Sephin-1

Biological Activity

[Description]:

(E/Z)-Icerguastat ((E/Z)-Sephin1) is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). (E/Z)-Icerguastat can be used for protein misfolding diseases research[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Research Areas >> Inflammation/Immunology

[Target]

PPP1R15A[1]


[References]

[1]. Das I, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science. 2015 Apr 10;348(6231):239-42.

Chemical & Physical Properties

[ Density]:
1.35g/cm3

[ Boiling Point ]:
374.2ºC at 760 mmHg

[ Molecular Formula ]:
C8H9ClN4

[ Molecular Weight ]:
196.63700

[ Flash Point ]:
180.1ºC

[ Exact Mass ]:
196.05200

[ PSA ]:
74.26000

[ LogP ]:
2.34790

[ Vapour Pressure ]:
8.5E-06mmHg at 25°C

[ Index of Refraction ]:
1.626

Precursor & DownStream

Precursor

DownStream

Related Compounds

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