Thiol-C9-PEG4

Names

[ CAS No. ]:
130727-41-2

[ Name ]:
Thiol-C9-PEG4

[Synonym ]:
Triethylene glycol mono-11-mercaptoundecyl ether
20-sulfanyl-3,6,9-trioxa-1-icosanol

Biological Activity

[Description]:

Thiol-C9-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
0.995 g/mL at 25ºC

[ Boiling Point ]:
446.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₃₆O₄S

[ Molecular Weight ]:
336.53000

[ Flash Point ]:
>110ºC

[ Exact Mass ]:
336.23300

[ PSA ]:
86.72000

[ LogP ]:
3.46920

[ Vapour Pressure ]:
7.55E-10mmHg at 25°C

[ Index of Refraction ]:
n 20/D 1.476

[ Storage condition ]:
Refrigerator, Under Inert Atmosphere

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ RIDADR ]:
UN 3334

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Plasmonic amplification for bioassays with epi-fluorescence readout.

Opt. Express 22(26) , 32026-38, (2015)

Corrugated metallic surfaces offer means for efficient amplification of fluorescence bioassay signal based on the near field coupling between surface plasmons and fluorophore emitters that are used as...

Versatile and efficient synthesis of omega-functionalized asymmetric disulfides via sulfenyl bromide adducts.

Langmuir 23 , 2318, (2007)

Various types of asymmetric disulfides can be synthesized under mild conditions and in excellent yields by a method involving dialkoxylthiophosphoranesulfenyl halide precursors. This straightforward, ...

Related Compounds

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