RP-001

Names

[ Name ]:
RP-001

Biological Activity

[Description]:

RP-001 is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 induces internalization and polyubiquitination of S1P1. RP-001 has little activity on S1P2-S1P4 and only moderate affinity for S1P5[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> LPL Receptor

Research Areas >> Neurological Disease

[In Vitro]

RP-001 elicits dose-dependent lymphopenia of CD4+ T cells. RP-001 induces acute lymphopenia with rapid recovery to untreated levels[1].

[In Vivo]

RP-001 causes dose-dependent rapid lymphopenia with an EC50 of 0.03 mg/kg[1].

[References]

[1]. Cahalan SM, et al. Actions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in mice. Nat Chem Biol. 2011 May;7(5):254-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₄N₄O₄

[ Molecular Weight ]:
468.93300

[ Exact Mass ]:
468.15600

[ PSA ]:
121.27000

[ LogP ]:
5.30698

Related Compounds

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