Peucedanocoumarin III

Names

[ Name ]:
Peucedanocoumarin III

[Synonym ]:
(9S,10R)-9-Acetoxy-8,8-dimethyl-2-oxo-9,10-dihydro-2H,8H-pyrano[2,3-f]chromen-10-yl (2E)-2-methyl-2-butenoate
2-Butenoic acid, 2-methyl-, (9S,10R)-9-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-10-yl ester, (2E)-

Biological Activity

[Description]:

Peucedanocoumarin III is an inhibitor of (alpha)-synuclein and Huntington protein aggregates that enhances the clearance of nuclear and cytoplasmic β23 aggregates and prevents cytotoxicity induced by disease-associated proteins (i.e., mutant Huntington proteins and α-synuclein). Peucedanocoumarin III may be used in Parkinson's disease research[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Sangwoo Ham, et al. Cell-Based Screen Using Amyloid Mimic β23 Expression Identifies Peucedanocoumarin III as a Novel Inhibitor of α-Synuclein and Huntingtin Aggregates. Mol Cells. 2019 Jun 30;42(6):480-494.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
486.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₂O₇

[ Molecular Weight ]:
386.395

[ Flash Point ]:
211.5±28.8 °C

[ Exact Mass ]:
386.136566

[ LogP ]:
4.30

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.574

Related Compounds

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