3β,5α-Dihydroxycholestan-6-one

Names

[ Name ]:
3β,5α-Dihydroxycholestan-6-one

[Synonym ]:
CHOLESTANE-6-OXO-3,5-DIOL
Cholestan-6-one, 3,5-dihydroxy-, (3β,5α)-
(3β,5α)-3,5-Dihydroxycholestan-6-one
CHOLESTANE-6-OXO-3BETA,5ALPHA-DIOL
5ALPHA-HYDROXY-6-KETO CHOLESTEROL
YS-64
yakkasterone
3β,5α-Dihydroxycholestan-6-one

Biological Activity

[Description]:

5α-Hydroxy-6-keto cholesterol is major metabolite of β-epoxide (5α,6β-epoxycholesterol) during direct exposure of intact cultured human bronchial epithelial cells (16-HBE) to ozone. 5α-Hydroxy-6-keto cholesterol inhibits cholesterol synthesis with an IC50 of 350 nM[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[In Vitro]

5α-Hydroxy-6-keto cholesterol (0.01, 0.1, 1, 10 μM) is cytotoxic to cultured 16-HBE cells[1].

[References]

[1]. Melissa K Pulfer, et al. Formation of biologically active oxysterols during ozonolysis of cholesterol present in lung surfactant. J Biol Chem. 2004 Jun 18;279(25):26331-8.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
528.9±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₇H₄₆O₃

[ Molecular Weight ]:
418.652

[ Flash Point ]:
287.7±25.2 °C

[ Exact Mass ]:
418.344696

[ PSA ]:
57.53000

[ LogP ]:
7.00

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.531

Related Compounds

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